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Molecular Pathogenesis of Frontotemporal Lobar DegenerationBasic Science Seminar in Neurology
Kristel Sleegers, MD, PhD;
Samir Kumar-Singh, MD, PhD;
Marc Cruts, PhD;
Christine Van Broeckhoven, PhD, DSc
Arch Neurol. 2008;65(6):700-704.
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INTRODUCTION
Molecular genetic research provides a valuable tool to increase our understanding of diseases of the brain, which are otherwise difficult to study because of limited accessibility to the diseased tissue during life. One of the classic methods used in molecular genetics is linkage analysis. This is a technique designed to map disease genes in families by examining transmission of genes based on cosegregation of highly polymorphic genetic markers with disease. These genetic markers are mostly short tandem repeats of 2 to 4 nucleotides that can be genotyped at even spacing throughout the genome. Using a statistical algorithm, chromosome regions can be identified that are shared between patients more often than expected by chance. Shared regions are more likely to contain a disease gene. Findings from a single family can be extrapolated to larger groups . . . [Full Text of this Article]
HISTORICAL PERSPECTIVE: TAU OR NO TAU
MAPPING THE GENE FOR 17q21-LINKED FTLDU
RELEVANCE TO THE PRACTICE OF NEUROLOGY
RELEVANCE TO THE STUDY OF NEUROSCIENCE
AUTHOR INFORMATION
Author Affiliations: Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, Flanders Institute for Biotechnology, Flanders, and Laboratory of Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium.
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