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Eleonora Tavazzi, MD; Sabrina Ravaglia, MD, PhD; Diego Franciotta, MD; Enrico Marchioni, MD

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We have read with interest the recent article by de Seze et al¹ titled "Acute Fulminant Demyelinating Disease: A Descriptive Study of 60 Patients." The article mainly tackles the problem of different diagnosis criteria between acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) during the acute phase of the first episode in a population aged 15 years and older. From this study, it has emerged that the following variables help to distinguish patients with ADEM from patients with MS: atypical symptoms, oligoclonal bands, and gray matter involvement. When referring to adults, de Seze and colleagues cite only the work by Schwarz et al,² underlining some differential characteristics having to do with age and the distribution of lesions on magnetic resonance imaging. The same topic appears among our subjects of interest, as can be seen from our articles . . . [Full Text of this Article]

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Acute Fulminant Demyelinating Disease: A Descriptive Study of 60 Patients
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