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COMMENTS AND OPINIONS
Monophasic Acute, Recurrent, and Multiphasic Disseminated Encephalomyelitis and Multiple Sclerosis
Vesna V. Brinar, MD, PhD;
Mario Habek, MD
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We read with great interest the article by de Seze et al1 about disseminated encephalomyelitis (DEM) and multiple sclerosis (MS) in the October 2007 issue of the Archives. We agree that in the current literature many diseases are regarded as acute DEM (ADEM) and that diagnostic criteria for ADEM are needed.
However, the classification of patients into ADEM, multiphasic DEM (MDEM), and MS groups in the article by de Seze and colleagues is confusing. Studies performed both in children and in adults have differentiated 3 types of DEM: (1) monophasic ADEM, which represents 1 demyelinating episode; (2) recurrent DEM (RDEM), which represents relapses with symptoms similar to those in the first demyelinating episode; and (3) MDEM, which represents relapses with symptoms of locations other than those in the first demyelinating episode.2-4 de Seze and colleagues do not distinguish RDEM and MDEM . . . [Full Text of this Article] AUTHOR INFORMATION
RELATED ARTICLE
Acute Fulminant Demyelinating Disease: A Descriptive Study of 60 Patients
Jérôme de Seze, Marc Debouverie, Hélène Zephir, Christine Lebrun, Frédéric Blanc, Véronique Bourg, Sandrine Wiertlewski, Sophie Pittion, David Laplaud, Emmanuelle Le Page, Romain Deschamps, Philippe Cabre, Jean Pelletier, Irina Malikova, Pierre Clavelou, Valérie Jaillon, Gilles Defer, Pierre Labauge, Olivier Gout, Clotilde Boulay, Gilles Edan, and Patrick Vermersch
Arch Neurol. 2007;64(10):1426-1432.
ABSTRACT
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RELATED LETTER
Monophasic Acute, Recurrent, and Multiphasic Disseminated Encephalomyelitis and Multiple Sclerosis—Reply
Jérôme de Seze
Arch Neurol. 2008;65(5):676.
EXTRACT
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