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COMMENTS AND OPINIONS
Multiple Sclerosis and Recurrent Disseminated Encephalomyelitis Are Different Diseases—Reply
Jérôme de Seze, MD, PhD
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In reply
My coauthors and I thank Dr Poser for the interesting comments. We agree with most of these remarks, but we think that they are not applicable to clinical practice. We agree that acute DEM is a different condition compared with MS; however, as Dr Poser says, the 2 diseases are essentially different concerning genetic susceptibility and neuropathological data. If we consider the question to be a clinical point of view, we are not able to use these parameters to distinguished the 2 diseases.
We also agree that extended spinal cord lesions are rare in MS, as stated in the criteria byMcDonald et al. However, in various series, this feature has been found in between 5% and 10% of MS cases1-2 and is not an exclusion criterion for MS.
Finally, we agree that 16 years is arbitrary, but in France there is a cutoff . . . [Full Text of this Article] AUTHOR INFORMATION
RELATED ARTICLE
Acute Fulminant Demyelinating Disease: A Descriptive Study of 60 Patients
Jérôme de Seze, Marc Debouverie, Hélène Zephir, Christine Lebrun, Frédéric Blanc, Véronique Bourg, Sandrine Wiertlewski, Sophie Pittion, David Laplaud, Emmanuelle Le Page, Romain Deschamps, Philippe Cabre, Jean Pelletier, Irina Malikova, Pierre Clavelou, Valérie Jaillon, Gilles Defer, Pierre Labauge, Olivier Gout, Clotilde Boulay, Gilles Edan, and Patrick Vermersch
Arch Neurol. 2007;64(10):1426-1432.
ABSTRACT
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RELATED LETTER
Multiple Sclerosis and Recurrent Disseminated Encephalomyelitis Are Different Diseases
Charles M. Poser
Arch Neurol. 2008;65(5):674.
EXTRACT
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