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edited by Aristedes Veves, MD, DSc, and Rayaz A. Malik, MBChB, PhD, 516 pp, with illus, $169, ISBN 978-1-588-2-626-9, Totowa, New Jersey, Humana Press, 2007.

Michael Stanton, MD, Reviewer

Arch Neurol. 2008;65(11):1543.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Diabetic neuropathy is the most common cause of neuropathy in the developed world. It affects 30% to 50% of diabetic patients and it is a considerable source of morbidity and mortality. The new edition of this book is a comprehensive update and addresses the scientific basis of diabetic neuropathy, diabetic trials, and, importantly, the clinical management of the complications of diabetic neuropathy, including those due to pain, joint deformity, infection, and dysautonomia. The list of contributors is substantial and includes basic science researchers and experts in clinical management.

The book is organized with the first chapters describing the historical aspects of diabetic neuropathy, epidemiology, and genomics. The middle chapters focus on rodent models of diabetes mellitus and their application to human diabetic neuropathy. These chapters include reviews of the deleterious effects of oxidative stress via activation of the polyol pathways in TG hAR and TG P0hAR . . . [Full Text of this Article]

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