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Margaret L. Frazer, MD; J. Thomas Benson, MD; Clare A. Braun Hashemi, MD; Heidi Lee, MD; Karen D. Rodman, MD; Oldrich J. Kolar, MD, PhD

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In the recently published communication by Langer-Gould et al¹ addressing predictors of long-term disability in patients with relapsing-remitting multiple sclerosis (MS), sphincter symptoms and a short interval between the first and second attack were indicated as the most reliable predictors of long-term disability. It was recommended that these factors should be considered before treatment using the currently accepted disease-modifying agents is considered. However, without further specification of the sphincter symptoms, particularly with no objective findings indicating sphincter dysfunction, the actual clinical implication of the recommendation in individual MS patients could prove to have a negative effect on timely treatment.

Subjective symptoms of urgency, frequency, feeling of incomplete evacuation of urinary bladder, episodic incontinence, or transient inability to initiate urination are very frequent complaints in MS . . . [Full Text of this Article]

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