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COMMENTS AND OPINIONS
Medication Use as a Confounding Factor in the Use of the Cerebrospinal Fluid tau/β-Amyloid42 Ratio—Reply
Anne M. Fagan, PhD;
Catherine M. Roe, PhD;
Chengjie Xiong, PhD;
Mark A. Mintun, MD;
John C. Morris, MD;
David M. Holtzman, MD
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In reply
We thank Dr Vanacore and colleagues and Dr Wong for their interest in our study and appreciate the opportunity to respond to their concerns. Concerning Dr Vanacore's first point, we obtained similar sensitivity, specificity, and positive and negative predictive values reported by these investigators using equations developed for the traditional diagnostic test setting, where the variable used for prediction is measured at the same point in time as the outcome. However, these statistics are less appropriate when future onset of disease is assessed in association with potential predictors measured only at baseline over varying follow-up times among subjects, as in our study. These types of longitudinal studies require that the prediction of future disease onset takes into account not only whether participants will eventually convert . . . [Full Text of this Article] AUTHOR INFORMATION
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