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Nicola Vanacore, MD; Francesca Galeotti, MD; Marina Maggini, DBiol; Roberto Raschetti, MSc

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Fagan et al¹ followed up a group of 61 normal elderly individuals (Clinical Dementia Rating [CDR] 0, 60 years old) for a mean time of 3 to 4 years to study cognitive decline. Individuals who progressed during the follow-up from a CDR of 0 to a CDR of 0.5 or higher were defined as converters toward very mild or mild dementia. All the other subjects were considered nonconverters. A cutoff value of 0.214 or greater for the ratio of cerebrospinal fluid (CSF) phosphorylated tau₁₈₁/β-amyloid₄₂ (ptau₁₈₁/Aβ₄₂) at baseline was adopted to predict converters and nonconverters at follow-up. The authors' conclusion is that, "CSF tau/Aβ₄₂ ratios show strong promise as antecedent (preclinical) biomarkers that predict future dementia in cognitively normal older adults."

We would like to raise 2 objections. First, on the basis of the data reported . . . [Full Text of this Article]

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