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COMMENTS & OPINIONS
Progression to Dementia in Probable and Possible Mild Cognitive Impairment—Reply
Oscar L. Lopez, MD;
Lewis H. Kuller, MD;
James T. Becker, PhD
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In reply
We thank Panza and colleagues for their interesting observation regarding the discrepancy in the incidence of dementia in MCI between the CHS-CS1 and the ILSA.2 One of the most important epidemiological problems in the study of MCI and dementia is the ascertainment of cases. Studies using a 2-stage screening protocol risk missing MCI and early dementia cases (eg, a cut-off of 23 in Mini-Mental State Examination score).2 In the CHS-CS, all subjects had detailed neurological and neuropsychological evaluations, and none of them went through a screening phase. Had we used a cut-off score of 80 in the Modified Mini-Mental State Examination (which is the accepted cut-off for identifying cognitively impaired subjects, similar to a Mini-Mental State Examination score of about 23),3 we would have failed to identify 86% of the subjects eventually classified as MCI and . . . [Full Text of this Article] AUTHOR INFORMATION
RELATED LETTER
Progression to Dementia in Probable and Possible Mild Cognitive Impairment
Francesco Panza, Cristiano Capurso, Alessia D’Introno, Anna M. Colacicco, Andrea Santamato, Antonio Capurso, and Vincenzo Solfrizzi
Arch Neurol. 2007;64(8):1209-1210.
EXTRACT
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RELATED ARTICLE
Incidence of Dementia in Mild Cognitive Impairment in the Cardiovascular Health Study Cognition Study
Oscar L. Lopez, Lewis H. Kuller, James T. Becker, Corinne Dulberg, Robert A. Sweet, H. Michael Gach, and Steven T. DeKosky
Arch Neurol. 2007;64(3):416-420.
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