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David E. Pleasure, MD

Arch Neurol. 2007;64(7):935-936.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

This issue of the Archives contains 3 articles on the etiology and pathophysiology of peripheral neuropathies: acquired forms related to eosinophilia; Charcot-Marie-Tooth disease (CMT) associated with neurofilament light chain gene (NEFL) mutations; and hereditary predisposition to pressure palsies (HNPP). Chao et al¹ report on 12 patients with eosinophilia and the subacute onset of sensorimotor polyneuropathy or mononeuropathy multiplex. Six of the 12 met criteria from the American College of Rheumatology for Churg-Strauss syndrome, including adult-onset asthma and/or sinusitis,² while the remaining 6 had primary eosinophilia. Skin biopsies revealed perivascular infiltrates of eosinophils, lymphocytes and monocytes, and a reduction in nerve fiber density.

Miltenberger-Miltenyi et al³ describe 2 families and 1 sporadic patient with CMT associated with NEFL mutations. Charcot-Marie-Tooth disease was dominantly inherited in the 2 families, in one of which affected individuals had a previously unreported NEFL point mutation. Nerve conduction studies were . . . [Full Text of this Article]

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