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  Vol. 64 No. 6, June 2007 TABLE OF CONTENTS
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  Controversies in Neurology
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 •Multiple Sclerosis/ Demyelinating Disease
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Neuromyelitis Optica Is a Variant of Multiple Sclerosis

Steven L. Galetta, MD; Jeffrey Bennett, MD, PhD

Arch Neurol. 2007;64(6):901-903.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Neuromyelitis optica (NMO) is a controversial entity that has been periodically redefined. Initially, the condition was coined by Devic1 as an acute monophasic process characterized by severe bilateral optic neuritis and myelitis. In 1999, the disorder was defined to include patients with relapsing-remitting disease, and new criteria were proposed that included clinical findings, magnetic resonance imaging (MRI), and spinal fluid pleocytosis.2 The recent detection of antibodies in some patients with NMO has been used to further extend the diagnostic criteria of this entity.3-5 While the recent amendments have attempted further differentiation of patient populations with multiple sclerosis (MS) and NMO, there remain no definitive clinical criteria, laboratory testing, neuroimaging, or histopathologic features that separate these 2 disorders as individual nosologic entities.

CLINICAL CRITERIA

The potential clinical course of patients with NMO is not distinct from other forms of demyelinating disease. Some patients with NMO . . . [Full Text of this Article]


LABORATORY TESTING

IMAGING

PATHOLOGIC FEATURES

CONCLUSIONS

AUTHOR INFORMATION
Author Affiliations: Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia (Dr Galetta); and University of Colorado at Denver and the Health Sciences Center, Denver (Dr Bennett).



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RELATED LETTERS

More on Multiple Sclerosis and Neuromyelitis Optica
Diego Franciotta, Sven Jarius, and Francesca Aloisi
Arch Neurol. 2007;64(12):1802.
EXTRACT | FULL TEXT  

More on Multiple Sclerosis and Neuromyelitis Optica—Reply
Brian Weinshenker, Steve Galetta, Jeffrey Bennett, Douglas Kerr, and Elliot M. Frohman
Arch Neurol. 2007;64(12):1802-1803.
EXTRACT | FULL TEXT  

RELATED ARTICLES

Neuromyelitis Optica Is Distinct From Multiple Sclerosis
Brian G. Weinshenker
Arch Neurol. 2007;64(6):899-901.
EXTRACT | FULL TEXT  

Is Neuromyelitis Optica Distinct From Multiple Sclerosis?: Something for "Lumpers" and "Splitters"
Elliot M. Frohman and Douglas Kerr
Arch Neurol. 2007;64(6):903-905.
EXTRACT | FULL TEXT  

Is Neuromyelitis Optica a Distinct Entity?
E. S. Roach
Arch Neurol. 2007;64(6):906.
EXTRACT | FULL TEXT  


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Humoral Pattern II Multiple Sclerosis Pathology Not Associated With Neuromyelitis Optica IgG
Kale et al.
Arch Neurol 2009;66:1298-1299.
FULL TEXT  

Spectrum of Pediatric Neuromyelitis Optica
Lotze et al.
Pediatrics 2008;122:e1039-e1047.
ABSTRACT | FULL TEXT  

Polyspecific, antiviral immune response distinguishes multiple sclerosis and neuromyelitis optica
Jarius et al.
J. Neurol. Neurosurg. Psychiatry 2008;79:1134-1136.
ABSTRACT | FULL TEXT  

Characterisation of the spectrum of demyelinating disease in Western Australia
Wu et al.
J. Neurol. Neurosurg. Psychiatry 2008;79:1022-1026.
ABSTRACT | FULL TEXT  

More on Multiple Sclerosis and Neuromyelitis Optica
Franciotta et al.
Arch Neurol 2007;64:1802-1802.
FULL TEXT  

More on Multiple Sclerosis and Neuromyelitis Optica Reply
Weinshenker et al.
Arch Neurol 2007;64:1802-1803.
FULL TEXT  

Is Neuromyelitis Optica Distinct From Multiple Sclerosis?: Something for "Lumpers" and "Splitters"
Frohman and Kerr
Arch Neurol 2007;64:903-905.
FULL TEXT  

Is Neuromyelitis Optica a Distinct Entity?
Roach
Arch Neurol 2007;64:906-906.
FULL TEXT  





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