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K. Meng Tan, MD; Gregory A. Worrell, MD, PhD; Joseph E. Parisi, MD; Daniel H. Lachance, MD

Arch Neurol. 2007;64(4):600-601.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A 77-year-old right-handed woman with no prior neurologic abnormalities presented with 2 months of progressive memory loss, aphasia, and upper limb clumsiness. Examination confirmed a severe global cognitive impairment, a predominantly expressive aphasia, bilateral ideomotor apraxia worse on the right side than the left, and an alien right upper limb with myoclonic jerks. Video electroencephalographic recording showed severe delta frequency slowing and periodic sharp waves over the left parietal head region (Figure 1A). The sharp waves were not synchronized with the myoclonic jerks. Brain magnetic resonance imaging demonstrated high-intensity signal within the left parietotemporal cortex on diffusion-weighted and fluid-attenuated inversion recovery sequences, with much less prominent but similar changes contralaterally (Figure 1B). The cerebrospinal fluid neuron-specific enolase level was markedly elevated at 112 ng/mL (reference range, <20 ng/mL). The . . . [Full Text of this Article]

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