In recent years, there have been hundreds of published reports citing or refuting a genetic association of specific susceptibility genes and the occurrence of Alzheimer disease (AD).^2-6 It is clear that mutations in the amyloid precursor protein (APP) gene (chromosome 21), presenilin 1 gene (chromosome 14), and presenilin 2 gene (chromosome 1) are causal of AD.⁷ It is also well established that the 4 allele of apolipoprotein E is a major susceptibility factor for AD.^{2, 4-5,7} However, a clear consensus of other potential susceptibility genes for AD remains to be reached. Progress in this regard has been achieved by Bertram et al,² who have collected systematic analyses of AD genetic association studies in the AlzGene database, a publicly available, updated database that catalogs all genetic association . . . [Full Text of this Article]