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Marino M. Bianchin, MD; Tonicarlo R. Velasco, MD; Ana Paula P. Martins, MD; Américo C. Sakamoto, MD

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Burneo and colleages¹ recently reported that ethnicity and socioeconomic status are not isolate predictors for seizure control in surgical mesial temporal lobe epilepsy associated with hippocampal sclerosis (MTLE-HS). These interesting results perhaps suggest that studies analyzing surgical outcome in MTLE-HS conducted in populations with diverse socioeconomic status or ethnic backgrounds might have broader external validity. However, they also found that men had better outcomes than women. If this finding is accurate, it could have important neurobiological or clinical consequences. However, we feel this last result needs some further consideration.

Although some sex differences have been reported in MTLE-HS,^2-3 sex influence in postsurgical outcome is hardly one of them.^4-6 There seems to exist poor biological plausibility to support such result. The authors pointed out methodological problems in a previous article reporting a lack of . . . [Full Text of this Article]

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RELATED LETTER

Sex as a Prognostic Factor for Surgical Outcome in Mesial Temporal Lobe Epilepsy—Reply
Jorge G. Burneo and Ruben I. Kuzniecky
Arch Neurol. 2007;64(2):288-289.
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