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COMMENTS & OPINIONS
More on Multiple Sclerosis and Neuromyelitis Optica—Reply
Brian Weinshenker, MD;
Steve Galetta, MD;
Jeffrey Bennett, MD, PhD;
Douglas Kerr, MD, PhD;
Elliot M. Frohman, MD, PhD
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In reply
We have reviewed the interesting comments of Franciotta et al, who propose that MS and NMO may be distinguished by biologic differences in their respective humoral immune responses: oligoclonal banding, anti-aquaporin-4 (AQP-4) specificity, and background polyreactivity. Given the differing views of the authors1-3 on the distinctness of NMO and MS, as expressed in our recent "Controversies in Neurology" series, understandably we will express somewhat disparate responses to these comments.
Dr Weinshenker emphasizes that the 3 observations cited by Franciotta et al are all consistent with immunological differences between and distinctness of NMO and MS. The differences described in intrathecal response to viruses are nonspecific and suggest an intrathecal polyreactivity of the immune system in MS that is not as apparent in NMO. This observation provides parallel information to the . . . [Full Text of this Article] AUTHOR INFORMATION
RELATED LETTER
More on Multiple Sclerosis and Neuromyelitis Optica
Diego Franciotta, Sven Jarius, and Francesca Aloisi
Arch Neurol. 2007;64(12):1802.
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Neuromyelitis Optica Is Distinct From Multiple Sclerosis
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