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  Vol. 64 No. 12, December 2007 TABLE OF CONTENTS
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Acquired Hypopigmentation (Leukoderma) as a Presenting Feature of Metastatic Amelanotic Melanoma With Brain Involvement

Ioannis Karakis, MD; Brian McGeeney, MD; Maria-France Demierre, MD; Jens J. Thiele, MD; Deon Wolpowitz, MD; Jag Bhawan, MD

Arch Neurol. 2007;64(12):1786-1787.

Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A 57-year-old man with no relevant medical history was initially seen with clumsiness and judgment errors while driving for the past 3 weeks. His neurological examination results revealed cognitive impairment and a left homonymous hemianopsia. Skin examination findings were remarkable for multiple oval well-defined depigmented macules on the back of his hands, feet, and neck that were first noticed during the preceding months (Figure 1). On his left shoulder, there was a 1-cm round erythematous nodule (Figure 2).


 
Figure appears in full text version.
Figure 1. Macroscopic views of leukoderma of the hands (A) and neck (B).



 
Figure appears in full text version.
Figure 2. Macroscopic view of amelanotic melanoma of the left shoulder. Scale set at centimeters.


Magnetic resonance imaging of the brain showed multiple T1- and T2-weighted isointense lesions (Figure 3) that enhanced after contrast . . . [Full Text of this Article]

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