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Acquired Hypopigmentation (Leukoderma) as a Presenting Feature of Metastatic Amelanotic Melanoma With Brain Involvement
Ioannis Karakis, MD;
Brian McGeeney, MD;
Maria-France Demierre, MD;
Jens J. Thiele, MD;
Deon Wolpowitz, MD;
Jag Bhawan, MD
Arch Neurol. 2007;64(12):1786-1787.
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A 57-year-old man with no relevant medical history was initially seen with clumsiness and judgment errors while driving for the past 3 weeks. His neurological examination results revealed cognitive impairment and a left homonymous hemianopsia. Skin examination findings were remarkable for multiple oval well-defined depigmented macules on the back of his hands, feet, and neck that were first noticed during the preceding months (Figure 1). On his left shoulder, there was a 1-cm round erythematous nodule (Figure 2).
Figure appears in full text version.
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Figure 1. Macroscopic views of leukoderma of the hands (A) and neck (B).
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Figure appears in full text version.
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Figure 2. Macroscopic view of amelanotic melanoma of the left shoulder. Scale set at centimeters.
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Magnetic resonance imaging of the brain showed multiple T1- and T2-weighted isointense lesions (Figure 3) that enhanced after contrast . . . [Full Text of this Article] AUTHOR INFORMATION
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