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COMMENTS & OPINIONS
Optic Neuritis and Vaccination Investigation: Failure to Consider Significant Sex Differences and Multiple Vaccine Combinations
Renata J. M. Engler, MD;
Mary Klote, MD;
Michael R. Nelson, MD, PhD
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In follow-up to recent correspondence related to the study of vaccinations and subsequent optic neuritis by the Centers for Disease Control and Prevention (CDC),1-2 we are deeply concerned regarding the lack of consideration of sex differences in incidence of disease for the ICD-9 code 377.3, a common finding for autoimmune disorders, particularly in young adults aged 18 to 39 years. The Defense Medical Surveillance System (DMSS) demonstrates that in the population of service members of greatest concern, there is a consistent pattern, regardless of year for review, of increased disease incidence by first visit in women compared with men. This sex difference is also independent of race. The Figure was extracted from the remote access program to data contained within the DMSS offered by the Army Medical Surveillance Activity.3 Similar sex differences were identified for ICD-9 codes . . . [Full Text of this Article]AUTHOR INFORMATION
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Data vs Conclusions in the Optic Neuritis Vaccination Investigation
Meryl Nass
Arch Neurol. 2006;63(12):1809-1810.
EXTRACT
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Optic Neuritis and Vaccination Investigation: Failure to Consider Significant Sex Differences and Multiple Vaccine Combinations—Reply
Daniel C. Payne, Charles E. Rose, Jr, John Kerrison, Aaron Aranas, Susan Duderstadt, and Michael M. McNeil
Arch Neurol. 2007;64(11):1674-1675.
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RELATED ARTICLE
Anthrax Vaccination and Risk of Optic Neuritis in the United States Military, 1998-2003
Daniel C. Payne, Charles E. Rose, Jr, John Kerrison, Aaron Aranas, Susan Duderstadt, and Michael M. McNeil
Arch Neurol. 2006;63(6):871-875.
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