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COMMENTS AND OPINIONS
Clinical Differentiation Between Primary Lateral Sclerosis and Upper Motor Neuron Predominant Amyotrophic Lateral Sclerosis—Reply
Maria Carmela Tartaglia, MD;
Michael J. Strong, MD
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In reply
We examined the relationship between time to involvement of LMN dysfunction and survival or disease duration in the population of 661 patients with ALS of whom 27 had signs or symptoms of spasticity at disease onset. The group of 27 ALS patients could be categorized into 2 groups: those who developed LMN dysfunction within 3 years (group A; n = 21; mean ± SD time to onset of LMN dysfunction, 1.38 ± 0.8 years; range, 0.35-3 years) and those who developed LMN dysfunction later in their disease course (group B; n = 6; mean ± SD time to onset, 17.31 ± 21 years; range, 3.86-58.5 years).
Of the 27 patients with ALS, 17 have died, including 14 from group A. Group A patients all died within 9 years (mean ± SD disease survival, 3.11 ± 2.4 years). The surviving group A patients (n = 7) have had the disease for less than 3 years. Of the group B . . . [Full Text of this Article] AUTHOR INFORMATION
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Differentiation Between Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis: Examination of Symptoms and Signs at Disease Onset and During Follow-up
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