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COMMENTS AND OPINIONS
Clinical Differentiation Between Primary Lateral Sclerosis and Upper Motor Neuron Predominant Amyotrophic Lateral Sclerosis
Marc Gotkine, MBBS;
Zohar Argov, MDHons
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We read with interest the article by Tartaglia and colleagues1 regarding the differences in disease course between patients diagnosed with primary lateral sclerosis (PLS) compared with those diagnosed with amyotrophic lateral sclerosis (ALS).
There is little doubt that the early appearance of prominent lower motor neuron (LMN) signs in a patient previously found to have a pure upper motor neuron (UMN) syndrome is a poor prognostic factor. The question still remains when, if ever, to draw a line between UMN-predominant ALS and PLS. Thus we would like to know whether analysis of the data acquired from periodic clinical and electrophysiological testing of patients who initially presented with an UMN syndrome (eventually diagnosed as having either PLS or ALS) allows an approximation of "time to LMN involvement" (TLMNI) for each patient. A graph plotting TLMNI against survival may provide some indication as to whether the . . . [Full Text of this Article] AUTHOR INFORMATION
RELATED LETTER
Clinical Differentiation Between Primary Lateral Sclerosis and Upper Motor Neuron Predominant Amyotrophic Lateral Sclerosis—Reply
Maria Carmela Tartaglia and Michael J. Strong
Arch Neurol. 2007;64(10):1545.
EXTRACT
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RELATED ARTICLE
Differentiation Between Primary Lateral Sclerosis and Amyotrophic Lateral Sclerosis: Examination of Symptoms and Signs at Disease Onset and During Follow-up
Maria Carmela Tartaglia, Ann Rowe, Karen Findlater, J. B. Orange, Gloria Grace, and Michael J. Strong
Arch Neurol. 2007;64(2):232-236.
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