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Marc Gotkine, MBBS; Zohar Argov, MDHons

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with interest the article by Tartaglia and colleagues¹ regarding the differences in disease course between patients diagnosed with primary lateral sclerosis (PLS) compared with those diagnosed with amyotrophic lateral sclerosis (ALS).

There is little doubt that the early appearance of prominent lower motor neuron (LMN) signs in a patient previously found to have a pure upper motor neuron (UMN) syndrome is a poor prognostic factor. The question still remains when, if ever, to draw a line between UMN-predominant ALS and PLS. Thus we would like to know whether analysis of the data acquired from periodic clinical and electrophysiological testing of patients who initially presented with an UMN syndrome (eventually diagnosed as having either PLS or ALS) allows an approximation of "time to LMN involvement" (TLMNI) for each patient. A graph plotting TLMNI against survival may provide some indication as to whether the . . . [Full Text of this Article]

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Clinical Differentiation Between Primary Lateral Sclerosis and Upper Motor Neuron Predominant Amyotrophic Lateral Sclerosis—Reply
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