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Reitz and colleagues¹ reported the results of a very interesting community-based study involving 1271 elderly persons without dementia or cognitive decline in New York, in which a history of stroke was related to a progressive decline in memory and abstract/visuospatial performance, particularly among men and those without an apolipoprotein E 4 allele. The authors discussed these results as consistent with studies showing an increased risk of Alzheimer disease (AD) in persons with stroke,² postulating that if stroke is related to a higher risk of AD, it must be related to a decline in memory, and suggesting a degenerative origin for the memory performance decline associated with stroke. In the Italian Longitudinal Study on Aging (ILSA),³ we evaluated 2963 individuals from a population-based sample and found no association between stroke and incident mild cognitive impairment. However, there was a nonsignificant trend for stroke as a risk factor of progression of mild . . . [Full Text of this Article]

AUTHOR INFORMATION

Francesco Panza, MD, PhD; Cristiano Capurso, MD, PhD; Vincenzo Solfrizzi, MD, PhD

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