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In the March 2006 issue of the ARCHIVES, Josephs et al¹ reported on 16 patients with Parkinson disease (PD) suffering from disabling tremor but otherwise mild parkinsonian signs. The clinical course of these patients revealed mild progression other than tremor and a disappointing response to levodopa therapy. The family histories in the cases were remarkable with 10 of 16 patients reporting tremor or PD in at least 1 immediate family member. The authors suggested the term benign tremulous parkinsonism to be applied to this clinical constellation.

Alves et al² examined the relationship between motor subtypes and cognitive decline in PD. They prospectively followed a population-based cohort of 171 nondemented patients with PD for 8 years. The motor symptoms were classified as tremor-dominant (TD), postural instability and gait difficulties (PIGD), or intermediate according to published criteria based on the Unified Parkinson's Disease Rating Scale (UPDRS) subscales II and III.³ . . . [Full Text of this Article]

AUTHOR INFORMATION

Kristoffer Haugarvoll, MD; Ryan J. Uitti, MD; Matthew J. Farrer, PhD; Zbigniew K. Wszolek, MD

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Benign Tremulous Parkinsonism
Keith A. Josephs, Joseph Y. Matsumoto, and J. Eric Ahlskog
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ABSTRACT | FULL TEXT