This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on Web of Science (6)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Neurogenetics  • Movement Disorders  • Parkinson Disease/ Parkinsonian Disorders  • Genetic Disorders  • Alert me on articles by topic  Social Bookmarking   What's this?

Arch Neurol. 2006;63:1225-1228.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Parkinson disease (PD) is the second most common neurodegenerative disease after Alzheimer disease. It has an age-adjusted prevalence of approximately 150 of 100 000 and 2% at age 75 years. The early clinical features predominantly involve motor deficits that include asymmetric onset of resting tremor (usually upper limb), bradykinesia, and rigidity. These are, for the most part, the consequence of loss of dopaminergic neurons in the substantia nigra pars compacta. An important morphological hallmark of PD is the presence of Lewy bodies in a proportion of surviving neurons.

Study of the etiology and pathogenesis of P D has provided invaluable insights into the molecular mechanisms that may underlie neuronal dysfunction and degeneration in this disease. Perhaps the most important of these is the identification of 6 different genes implicated in the cause of PD: -synuclein, parkin, UCHL1, DJ1, PINK1, and LRRK2. With the exception of LRRK2, all are . . . [Full Text of this Article]

LRRK2 PROTEIN


LRRK2 MUTATIONS

LRRK2 EPIDEMIOLOGICAL FEATURES
CLINICAL FEATURES OF LRRK2 MUTATIONS

PATHOLOGICAL FEATURES OF LRRK2 MUTATIONS

CONCLUSIONS

AUTHOR INFORMATION
Anthony H. V. Schapira, MD, DSc, FRCP, FMedSci

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Clinical Heterogeneity of the LRRK2 G2019S Mutation
Spiridon Papapetropoulos, Carlos Singer, Owen A. Ross, Mathias Toft, Joseph L. Johnson, Matthew J. Farrer, and Deborah C. Mash
Arch Neurol. 2006;63(9):1242-1246.
ABSTRACT | FULL TEXT