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Interleukin 4 and Interleukin 10 in Creutzfeldt-Jakob Disease
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We read with great interest the recent excellent article concerning interleukin (IL) 4 and IL-10 in the cerebrospinal fluid (CSF) of patients with Creutzfeldt-Jakob disease by Stoeck et al.1 They reported that patients with Creutzfeldt-Jakob disease had elevated levels of CSF IL-4 and IL-10. They also determined that CSF IL-4 and IL-10 levels had increased in other patients with dementia compared with controls. We want to inquire about several points in their excellent study, especially on the data for patients with Creutzfeldt-Jakob disease.
The first question is whether there is any relationship between IL-4 and IL-10 levels and disease duration. Second, we would like to know how the grade of elevation on IL-4 and IL-10 levels is correlated with the elevation of CSF 14-3-3 protein. Did the authors determine serial levels of CSF IL-4 and IL-10 in individual patients? We agree that levels of IL-4 and IL-10 reflect the degenerative . . . [Full Text of this Article] AUTHOR INFORMATION
Yasuo Iwasaki, MD;
Shigeji Baba, MD;
Ken Ikeda, MD, PhD
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