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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We read with great interest the recent excellent article concerning interleukin (IL) 4 and IL-10 in the cerebrospinal fluid (CSF) of patients with Creutzfeldt-Jakob disease by Stoeck et al.¹ They reported that patients with Creutzfeldt-Jakob disease had elevated levels of CSF IL-4 and IL-10. They also determined that CSF IL-4 and IL-10 levels had increased in other patients with dementia compared with controls. We want to inquire about several points in their excellent study, especially on the data for patients with Creutzfeldt-Jakob disease.

The first question is whether there is any relationship between IL-4 and IL-10 levels and disease duration. Second, we would like to know how the grade of elevation on IL-4 and IL-10 levels is correlated with the elevation of CSF 14-3-3 protein. Did the authors determine serial levels of CSF IL-4 and IL-10 in individual patients? We agree that levels of IL-4 and IL-10 reflect the degenerative . . . [Full Text of this Article]

AUTHOR INFORMATION

Yasuo Iwasaki, MD; Shigeji Baba, MD; Ken Ikeda, MD, PhD

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