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Arch Neurol. 2006;63:906-907.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

We describe a primary cerebral amyloidoma that mimicked high-grade glioma on neuroimaging. Histologic analysis confirmed amyloidoma. Because neuroimaging characteristics of intracerebral amyloidoma can be confused for high-grade glioma, these lesions must be confirmed histologically before initiating aggressive treatment for presumptive high-grade glioma.

Amyloidosis is a diverse group of acquired or hereditary diseases characterized by extracellular tissue deposits of insoluble proteins in 1 or several organs. The defining feature of amyloidomas is the localized tumorlike deposition of amyloid.

We describe a patient with intracerebral amyloidoma with magnetic resonance imaging and magnetic resonance spectroscopy (MRS) findings consistent with high-grade glioma. To our knowledge, it is the first description of an MRS-mimicking neoplasm in the setting of intracerebral amyloidoma.

The patient is a 59-year-old man with a 6-month history of confusion, headache, and speech difficulties. Abnormal neurologic findings included difficulty recalling 3 objects at 5 minutes and mild para phasic errors with fluent . . . [Full Text of this Article]

AUTHOR INFORMATION

Brian T. Ragel, MD; Deborah T. Blumenthal, MD; Samuel R. Browd, MD, PhD; Karen L. Salzman, MD; Randy L. Jensen, MD, PhD

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