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The focus of our review was not to instigate debate regarding the exact anatomical location of B cells within the CNS. Thus, we had globally referred to B cells as residing in the CNS to include any possible anatomical scenario, including the cerebrospinal fluid. Nevertheless, data from Serafini et al¹ regarding the presence of CD138+ plasma cells in the brain parenchyma of even 1 patient brain with MS are relevant. For example, historically, B cells and plasma cells have only been observed in perivascular spaces, and not in the parenchyma,² and in association with active lesions, not chronic inactive ones. However, Serafini et al¹ observed that numerous CD20+ B cells had accumulated perivascularly in chronic inactive lesions and in the subarachnoid space, although not in the chronic active lesions themselves or demyelinated parenchyma. In contrast, plasma cells (identified as CD138+) were observed in parenchymal and meningeal blood vessels . . . [Full Text of this Article]

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Nancy L. Monson, PhD; Michael K. Racke, MD; Elliot M. Frohman, MD, PhD

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