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REGULAR CORRESPONDENCE
Sudden Onset of Somnolence in Parkinson Disease
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We read with interest the recent article by Avorn et al.1 Sudden onset of somnolence/sleep (SOS) is an important clinical problem in Parkinson disease (PD) and remains an area of significant controversy. This study identifies dopamine agonists as increasing the risk of SOS in a large sample of tertiary care PD patients. The findings of the study are interesting and confirm previous reports of a higher risk of SOS associated with dopamine agonist therapy relative to levodopa and other antiparkinsonian drugs.2-3
The mean Hoehn and Yahr (H&Y) scores reported in Table 3 of the article, however, are not consistent with early- to mid-stage PD as would be expected for the disease durations reported (1.2-4.9 years).4 The H&Y staging of disease was apparently assessed by the referring neurologists and the average H&Y score was a minimum of 3.6 (dopamine agonists only) up to a maximum of 4.7 (levodopa + dopamine agonist . . . [Full Text of this Article] AUTHOR INFORMATION
John C. Morgan, MD, PhD;
Kapil D. Sethi, MD, FRCP(UK)
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