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	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In their retrospective, cross-sectional, case-control study of patients with multiple risk factors for cerebrovascular disease, Maulaz et al¹ found increased risk of brain ischemic stroke in the 4 weeks after aspirin discontinuation (odds ratio, 3.34; 95% confidence interval, 1.07-10.39). These findings are consistent with previous studies, which showed that aspirin withdrawal may pose risk to coronary patients.² Moreover, similar risks are reported after the cessation of nonsteroidal anti-inflammatory drug (NSAID) therapy.³ Taken together, these data suggest that there may be some common mechanism responsible for these withdrawal-related cardiovascular and cerebrovascular events.

In the "Comment" section of the article, Maulaz et al¹ focused on possible prothrombotic rebound effects after stopping aspirin, which have been reported in experimental studies. However, they omit the possibility that there may be some "rebound" inflammation after stopping aspirin for the duration of several weeks. The suggestion that the cardioprotective properties of low-dose aspirin may reflect its . . . [Full Text of this Article]

AUTHOR INFORMATION

Michal R. Pijak, MD

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