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REGULAR CORRESPONDENCE
Association Between Pathologic Gambling and Parkinsonian Therapy as Detected in the Food and Drug Administration Adverse Event Database—Reply
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In reply
I very much appreciate the data presented by Szarfman and colleagues, which were prepared using the Food and Drug Administration AERS database and the MGPS statistical algorithm. These new data provide further support to the conclusions presented in our article,1 and I thank them for presenting their findings. The prominent occurrence of pramipexole seen in their data adds support to the position that a relationship between that particular dopamine agonist and impulsive behaviors is strong. I further contend that disproportionate dopamine D3 agonism (especially seen with pramipexole) as a substrate for pathologic gambling seems too obvious to ignore.
AUTHOR INFORMATION
Correspondence: Dr Dodd, Department of Psychiatry and Psychology, Mayo Clinic, 200 First St SW, Rochester, MN 55905 (dodd.maryellen@mayo.edu).
M. Leann Dodd, MD
1. Dodd ML, Klos KJ, Bower JH, Geda YE, Josephs KA, Ahlskog JE. Pathological gambling caused by drugs used to treat Parkinson disease. Arch Neurol. 2005;62:1377-1381.
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Arch Neurol. 2006;63:300.
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Association Between Pathologic Gambling and Parkinsonian Therapy as Detected in the Food and Drug Administration Adverse Event Database
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