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REGULAR CORRESPONDENCE
Impulse Control Disorders and Dopaminergic Drugs—Reply
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In reply
We appreciated the interest in our article1 by Dr Morgan and colleagues. We agree that any drug that increases cerebral dopaminergic neurotransmission may facilitate development of impulse control disorders. We specifically focused on pathological gambling, however, and were struck by the association with dopamine agonist therapy and most notably pramipexole. As we commented in our article, levodopa may have been a contributory factor, and that seems likely in those cases where agonists were adjunctively administered.
Levodopa has been the foundation of PD treatment for decades, often as monotherapy. However, none of our patients in the study with pathological gambling or those in prior published series were treated with levodopa monotherapy; all were taking therapeutic doses of agonists. As we indicated in our article, Molina et al2 failed to specify drugs other than levodopa: adjunctive drugs were employed but not listed; hence, we could not include their series in . . . [Full Text of this Article] AUTHOR INFORMATION
M. Leann Dodd, MD;
Kevin J. Klos, MD;
James H. Bower, MD;
Yonas E. Geda, MD;
Keith A. Josephs, MST, MD;
J. Eric Ahlskog, PhD, MD
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