• Online Features  This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Related articles  • Similar articles in this journal  Topic Collections  • Neurology  • Movement Disorders  • Parkinson Disease/ Parkinsonian Disorders  • Psychiatry  • Obsessive-Compulsive Disorder  • Drug Therapy  • Adverse Effects  • Alert me on articles by topic  Social Bookmarking   What's this?

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In reply

We appreciated the interest in our article¹ by Dr Morgan and colleagues. We agree that any drug that increases cerebral dopaminergic neurotransmission may facilitate development of impulse control disorders. We specifically focused on pathological gambling, however, and were struck by the association with dopamine agonist therapy and most notably pramipexole. As we commented in our article, levodopa may have been a contributory factor, and that seems likely in those cases where agonists were adjunctively administered.

Levodopa has been the foundation of PD treatment for decades, often as monotherapy. However, none of our patients in the study with pathological gambling or those in prior published series were treated with levodopa monotherapy; all were taking therapeutic doses of agonists. As we indicated in our article, Molina et al² failed to specify drugs other than levodopa: adjunctive drugs were employed but not listed; hence, we could not include their series in . . . [Full Text of this Article]

AUTHOR INFORMATION

M. Leann Dodd, MD; Kevin J. Klos, MD; James H. Bower, MD; Yonas E. Geda, MD; Keith A. Josephs, MST, MD; J. Eric Ahlskog, PhD, MD

CiteULike    Connotea    Delicious    Digg    Facebook    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLES

Impulse Control Disorders and Dopaminergic Drugs
John C. Morgan, Sanjay S. Iyer, and Kapil D. Sethi
Arch Neurol. 2006;63(2):298-299.
EXTRACT | FULL TEXT  

Pathological Gambling Caused by Drugs Used to Treat Parkinson Disease
M. Leann Dodd, Kevin J. Klos, James H. Bower, Yonas E. Geda, Keith A. Josephs, and J. Eric Ahlskog
Arch Neurol. 2005;62(9):1377-1381.
ABSTRACT | FULL TEXT