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What's in a NAIM?
Hashimoto Encephalopathy, Steroid-Responsive Encephalopathy Associated With Autoimmune Thyroiditis, or Nonvasculitic Autoimmune Meningoencephalitis?
Arch Neurol. 2006;63:175-176.
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Hashimoto encephalopathy was first described by Lord Brain in 1966.1 Multiple case reports followed and the term Hashimoto encephalopathy became generally accepted for the syndrome of encephalopathy in association with Hashimoto thyroiditis. Although Brain's original patient with Hashimoto encephalopathy did not improve with corticosteroid treatment, most of the patients described later showed marked improvement with some form of immunosuppression. This has led to the renaming of Hashimoto encephalopathy by some authors as "steroid-responsive encephalopathy associated with autoimmune thyroiditis" (SREAT)2 or "nonvasculitic autoimmune meningoencephalitis" (NAIM), a heterogeneous group that would include autoimmune disorders such as Sjögren syndrome and systemic lupus erythematosus–associated meningoencephalitis as well as Hashimoto encephalopathy. These disorders are unified by the feature of steroid responsiveness.3
The debate over terminology and classification of Hashimoto encephalopathy revolves around 2 issues: (1) Do thyroid antibodies have any significance in this disorder? (2) Is steroid responsiveness a clinical feature that can define this . . . [Full Text of this Article] AUTHOR INFORMATION
Ji Y. Chong, MD;
Lewis P. Rowland, MD
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Pablo Castillo, Bryan Woodruff, Richard Caselli, Steven Vernino, Claudia Lucchinetti, Jerry Swanson, John Noseworthy, Allen Aksamit, Jonathan Carter, Joseph Sirven, Gene Hunder, Vahab Fatourechi, Bahram Mokri, Daniel Drubach, Sean Pittock, Vanda Lennon, and Brad Boeve
Arch Neurol. 2006;63(2):197-202.
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