 |
|
Potential Applications and Limitations of Proteomics in the Study of Neurological Disease
Yoshito Kinoshita, PhD;
Takuma Uo, PhD;
Suman Jayadev, MD;
Gwenn A. Garden, MD, PhD;
Thomas P. Conrads, PhD;
Timothy D. Veenstra, PhD;
Richard S. Morrison, PhD
Arch Neurol. 2006;63:1692-1696.
|
|
| Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings. |
|
|
|
INTRODUCTION
Proteomics represents the comprehensive study of cellular proteins and is aimed at analyzing their structure, function, expression, interactions, and localization in complex biological systems. The information obtained from these types of analyses can contribute to our understanding of the function of individual proteins by identifying protein x protein interactions and dynamic protein networks found in normal and diseased conditions. Genomic (DNA) or transcriptomic (messenger RNA) approaches alone do not take into account changes in protein stability, localization, and posttranslational modifications that are often critical determinants of protein function and, by extension, cellular behavior. Although proteomic methods still require significant technical advances to provide a truly "global" or "comprehensive" measure of gene expression similar to that achieved by DNA microarrays, recent advances in proteomics are . . . [Full Text of this Article]
RELEVANCE TO THE PRACTICE OF NEUROLOGY
RELEVANCE TO THE STUDY OF NEUROSCIENCE
AUTHOR INFORMATION
Author Affiliations: Departments of Neurological Surgery (Drs Kinoshita, Uo, and Morrison) and Neurology (Drs Jayadev and Garden), and The Center for Neurogenetics and Neurotherapeutics (Drs Garden and Morrison), University of Washington School of Medicine, Seattle; and Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc, National Cancer Institute at Frederick, Frederick, Md (Drs Conrads and Veenstra).
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Imaging Genetics of Brain Longevity and Mental Wellness: The Next Frontier?
Petrella et al.
Radiology 2008;246:20-32.
ABSTRACT
| FULL TEXT
|
