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Diabetic Neuropathies
Vladimir Skljarevski, MD;
Alberto Lledo, MD, PhD
Arch Neurol. 2006;63:1502-1504.
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INTRODUCTION
This essay focuses on 3 issues pertinent to a historical discussion of diabetic neuropathies: ancient observations, 18th- and 19th-century advances, and the discovery of insulin. Given that the underlying biochemical mechanisms of diabetic neuropathy remain poorly understood and that currently used therapies, although seemingly less bizarre than those of the past, are not substantially more effective, the final chapter on the history of diabetic neuropathy remains to be written.
THE ANCIENT PERIOD
In 1862, egyptologist Georg Ebers found a papyrus dating from about 1550 BC that contained a description of various diseases and their cures (Ebers papyrus). It made note of a polyuric state resembling diabetes that was to be treated with a 4-day course of a liquid extract of bones, wheat, grain, grit, green lead, and earth.1 The Greek term diabetes, coming from the prefix dia and the word betes, meaning "to pass . . . [Full Text of this Article]
WESTERN MEDICINE IN THE 18th AND 19th CENTURIES
THE MIRACLE CALLED INSULIN
AUTHOR INFORMATION
Author Affiliations: Lilly Research Laboratories, Indianapolis, Ind.
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