This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Citation map  • Citing articles on HighWire  • Citing articles on Web of Science (39)  • Contact me when this article is cited  Related Content  • Related article  • Similar articles in this journal  Topic Collections  • Alzheimer Disease  • Cognitive Disorders  • Diagnosis  • Alert me on articles by topic  Social Bookmarking   What's this?

Time to Revise Diagnostic Criteria

Arch Neurol. 2006;63:15-16.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Mild cognitive impairment (MCI) is the focus of intense research interest as regards the early detection and treatment of Alzheimer disease (AD). Although MCI can be a heterogeneous condition and may have static or even reversible causes, the memory-predominant subtype, amnestic MCI, is viewed as an important risk factor or prodrome for AD. The characterization of amnestic MCI in large part comes from the seminal work of Petersen and colleagues,¹ who propose that it does not constitute dementia but instead is a transitional stage between normal aging and AD. Based on this premise, clinical trials of AD treatments have been conducted in individuals with MCI to evaluate whether the conversion to AD can be prevented or delayed.²

There is little evidence, however, to support the notion of a transitional stage interposed between normal aging and AD. Alzheimer disease is characterized by progressive synaptic and neuronal dysfunction, and the cognitive deficits . . . [Full Text of this Article]

AUTHOR INFORMATION

John C. Morris, MD

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter     What's this?

RELATED ARTICLE

Neuropathologic Substrate of Mild Cognitive Impairment
William R. Markesbery, Frederick A. Schmitt, Richard J. Kryscio, Daron G. Davis, Charles D. Smith, and David R. Wekstein
Arch Neurol. 2006;63(1):38-46.
ABSTRACT | FULL TEXT  

THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES

Functional and cognitive criteria produce different rates of mild cognitive impairment and conversion to dementia
Saxton et al.
J. Neurol. Neurosurg. Psychiatry 2009;80:737-743.
ABSTRACT | FULL TEXT  

Executive Decline and Dysfunction Precedes Declines in Memory: The Women's Health and Aging Study II
Carlson et al.
J Gerontol A Biol Sci Med Sci 2009;0:gln008v1-gln008.
ABSTRACT | FULL TEXT  

Safety and efficacy of galantamine in subjects with mild cognitive impairment
Winblad et al.
Neurology 2008;70:2024-2035.
ABSTRACT | FULL TEXT  

Prevalence of Cognitive Impairment without Dementia in the United States
Plassman et al.
ANN INTERN MED 2008;148:427-434.
ABSTRACT | FULL TEXT  

Brain structural alterations before mild cognitive impairment
Smith et al.
Neurology 2007;68:1268-1273.
ABSTRACT | FULL TEXT  

Cortical biochemistry in MCI and Alzheimer disease: Lack of correlation with clinical diagnosis
Forman et al.
Neurology 2007;68:757-763.
ABSTRACT | FULL TEXT  

Utility of the Clinical Dementia Rating in Asian Populations
Lim et al.
Clin Med Res 2007;5:61-70.
ABSTRACT | FULL TEXT  

Conversion from subtypes of mild cognitive impairment to Alzheimer dementia
Fischer et al.
Neurology 2007;68:288-291.
ABSTRACT | FULL TEXT  

Older adults with cognitive complaints show brain atrophy similar to that of amnestic MCI.
Saykin et al.
Neurology 2006;67:834-842.
ABSTRACT | FULL TEXT  

Mild cognitive impairment: Risk of Alzheimer disease and rate of cognitive decline
Boyle et al.
Neurology 2006;67:441-445.
ABSTRACT | FULL TEXT  

Mild Cognitive Impairment: Looks Like AD
JWatch Psychiatry 2006;2006:3-3.
FULL TEXT