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Time to Revise Diagnostic Criteria

Arch Neurol. 2006;63:15-16.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Mild cognitive impairment (MCI) is the focus of intense research interest as regards the early detection and treatment of Alzheimer disease (AD). Although MCI can be a heterogeneous condition and may have static or even reversible causes, the memory-predominant subtype, amnestic MCI, is viewed as an important risk factor or prodrome for AD. The characterization of amnestic MCI in large part comes from the seminal work of Petersen and colleagues,¹ who propose that it does not constitute dementia but instead is a transitional stage between normal aging and AD. Based on this premise, clinical trials of AD treatments have been conducted in individuals with MCI to evaluate whether the conversion to AD can be prevented or delayed.²

There is little evidence, however, to support the notion of a transitional stage interposed between normal aging and AD. Alzheimer disease is characterized by progressive synaptic and neuronal dysfunction, and the cognitive deficits . . . [Full Text of this Article]

AUTHOR INFORMATION

John C. Morris, MD

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