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Eric E. Smith, MD, MPH, FRCPC; Florian Eichler, MD

Arch Neurol. 2006;63:148-151.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Cerebral amyloid angiopathy is caused by the deposition of -amyloid in the media and adventitia of small arteries and capillaries of the meninges and cerebral cortex. It is now recognized as a common cause of primary lobar intracerebral hemorrhage in elderly persons, and it is associated with frequent hemorrhage recurrence and the presence of asymptomatic petechial hemorrhages. Interestingly, although it has been nearly a century since the first pathological descriptions of cerebral amyloid angiopathy, knowledge of its link with intracerebral hemorrhage developed only within the last 35 years. This review provides a historical perspective on the still-evolving concept of cerebral amyloid angiopathy–related disease.

EARLY DESCRIPTIONS OF CEREBRAL AMYLOID ANGIOPATHY

In 1907, Alois Alzheimer published his now-famous article "Über eine eigenartige Erkrankung der Hirnrinde" ("About a Peculiar Disease of the Cerebral Cortex")^1-2 in which he described the autopsy of a 51-year-old woman with dementia. Among his findings, he . . . [Full Text of this Article]

CEREBRAL AMYLOID ANGIOPATHY AND INTRACEREBRAL HEMORRHAGE

CURRENT PERSPECTIVES

AUTHOR INFORMATION

Author Affiliations: Departments of Neurology (Dr Smith) and Pediatric Neurology (Dr Eichler), Massachusetts General Hospital, and Harvard Medical School (Drs Smith and Eichler), Boston.

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