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We read with interest the report of patients with splenium of corpus callosum (SCC) lesions, most being reversible with transiently reduced apparent diffusion coefficient (ADC) values.¹ We previously described 15 patients with clinically mild encephalitis/encephalopathy with identical reversible SCC lesions,² and we postulated that intramyelinic edema due to separation of myelin layers was a possible mechanism for the transiently decreased ADC. We recently saw a neonate with an identical SCC lesion, suggesting that the mechanism underlying the lesion might not be related to myelination.

Diffusion-weighted images of a neonate with mild asphyxia at age 12 days revealed a lesion of high signal intensity in the central portion of the SCC with a decreased ADC value (Figure, A). Magnetic resonance imaging also demonstrated T1 shortening in the bilateral ventral thalamus and deep sulci of insular regions, which likely resulted from perinatal asphyxia, without any abnormal signal on the diffusion-weighted . . . [Full Text of this Article]

AUTHOR INFORMATION

Jun-ichi Takanashi, MD; Masayuki Maeda, MD; Masaharu Hayashi, MD

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