This Article  • Full text  • PDF  • Reply to article  • Send to a friend  • Save in My Folder  • Save to citation manager  • Permissions  Citing Articles  • Contact me when this article is cited  Related Content  • Similar articles in this journal  Topic Collections  • Radiologic Imaging  • Immunologic Disorders  • Multiple Sclerosis/ Demyelinating Disease  • Magnetic Resonance Imaging  • Alert me on articles by topic

Arch Neurol. 2005;62:1466-1467.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

A case of demyelinating pseudotumor, considered an acute fulminant variant of multiple sclerosis (MS), occurring in a patient with definite MS is presented. Magnetic resonance imaging (MRI) showed a large, biopsy-proven demyelinating lesion with ring enhancement and mass effect. Treatment resistance to corticosteroids and -interferons occurred, which prompted our present use of combined corticosteroids/plasmapheresis followed by mitoxantrone.

A 50-year-old Caucasian man presented with acute onset confusion, inappropriate speech, and forgetfulness, as well as depressive symptoms for the preceding 2 years. On neurological examination, disorientation, a right lower facial paresis, and symmetrical hyperreflexia were present, but there was no papilledema or Babinski response probably owing to the acuteness of this process. Axial T1-weighted postgadolinium images (Figure 1) and fluid-attenuated inversion recovery MRI (Figure 2) show a left hemisphere contrast-enhancing ring lesion with massive edema and midline shift, and smaller typical MS lesions in the right hemisphere (and . . . [Full Text of this Article]

AUTHOR INFORMATION

Stephen L. Jaffe, MD; Alireza Minagar, MD