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Cerebral Syphilitic Gumma in a Human Immunodeficiency VirusPositive Patient
Arch Neurol. 2005;62:1310-1311.
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A 42-year-old homosexual man came to the emergency department because of fever, headache, and hearing loss. Fever and headache had been fluctuating for 2.5 months before and hearing loss was progressive for 1 week. He experienced a generalized maculopapular rash 2 months before admission. On clinical examination, the patient was subfebrile (temperature, 37.7°C) and had bilateral sensorineural hearing loss and a stiff neck. Brain imaging demonstrated right frontal edema surrounding a small contrast-enhancing lesion (Figure) and a smaller focus at the convexity of the anterior left frontal cortex. Blood analysis showed a lymphocyte count of547/µL (normal range, 1500-3500/ µL) with a CD4 cell count of 128/µL (normal range, 455-1885/µL). Serology for human immunodeficiency virus (HIV) 1 was positive. Lumbar puncture showed a white blood cell count of 1010/µL of which 64% were polymorphonuclear leukocytes; hypoglycorrhachia of 16 mg/dL (blood glucose level, 5.27 mmol/L [95 mg/dL]); a protein level . . . [Full Text of this Article]AUTHOR INFORMATION
Luc Régal, MD;
Philippe Demaerel, MD, PhD;
Bénédicte Dubois, MD, PhD
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