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A View Through the Prism of Epidemiology

Arch Neurol. 2005;62:1043-1044.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The relationship between insulin resistance and neurodegenerative disease is tantalizing in its potential to offer an integrated architecture for aging of the body and the brain. While there are contradictory findings in this area, the prevalence of insulin resistance is reportedly increased in many age-related neurodegenerative disorders, including Alzheimer disease, vascular dementia, and Parkinson disease.¹ Insulin resistance may contribute to the expression of these disorders through shared as well as distinct mechanisms. Identification of these mechanisms could aid the development of effective preventative and therapeutic strategies.

In this issue, Geroldi et al² report an ambitious study that views the relationship between insulin resistance and cognitive impairment through the prism of epidemiology. While this approach can identify important trends in large populations, it requires careful delineation of criteria to define a sample and its subgroups. Each criterion may refract the investigators’ perspective, which may in turn modify the likelihood of obtaining . . . [Full Text of this Article]

AUTHOR INFORMATION

Suzanne Craft, PhD

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