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Will Pallidal Deep Brain Stimulation Make a Triumphant Return?

Arch Neurol. 2005;62:533-536.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The field of Parkinson disease (PD) surgery has reemerged as an important area of research and clinical advancement. The notion of a surgical treatment for PD and tremors probably originated in 1909 with Horsley and in 1937 with Bucy, both of whom excised regions of motor cortex. The introduction in the 1950s of Speigel and Wycis’s stereotaxic head frame was an important development, and over the next several years, lesioning techniques in the thalamus and pallidum were refined. By the late 1960s, however, surgical treatment of PD halted with the introduction of levodopa. After the complications and failures of levodopa therapy were realized, PD surgery and lesion therapy reemerged. In the past decade, however, most centers using lesion therapy have switched to deep brain stimulation (DBS). Rapid and important advances in our understanding of basal ganglia physiology and neuroanatomy^1-2 have led to controversy about the best target for DBS. The . . . [Full Text of this Article]

RESULTS OF THE MOST RECENT TRIAL


SIZE OF THE TARGET

IMPROVEMENT IN DYSKINESIA AND DYSTONIA

IMPROVEMENT IN OTHER PARKINSONIAN FEATURES

MEDICATION REDUCTION

COGNITIVE, BEHAVIORAL, AND MOOD SYMPTOMS

CAUTION REGARDING INTERPRETATION OF COMPARATIVE TRIALS OF STN AND GPi DBS

RISK-BENEFIT RATIO OF GPi VS STN

AUTHOR INFORMATION
Michael S. Okun, MD; Kelly D. Foote, MD

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RELATED LETTERS

Pallidal vs Subthalamic Deep Brain Stimulation for Parkinson Disease: Winner and Loser or a Sharing of Honors?
Adolfo Minguez-Castellanos and Francisco Escamilla-Sevilla
Arch Neurol. 2005;62(10):1642-1643.
EXTRACT | FULL TEXT  

Multisite Randomized Trial of Deep Brain Stimulation
Kenneth Follett, Frances Weaver, Matthew Stern, William Marks, Penelope Hogarth, Katherine Holloway, Jeff Bronstein, John Duda, Stacy Horn, Eugene Lai, and Ali Samii
Arch Neurol. 2005;62(10):1643-1644.
EXTRACT | FULL TEXT  

Multisite Randomized Trial of Deep Brain Stimulation—Reply
Michael S. Okun and Kelly D. Foote
Arch Neurol. 2005;62(10):1644-1645.
EXTRACT | FULL TEXT  

RELATED ARTICLE

Pallidal vs Subthalamic Nucleus Deep Brain Stimulation in Parkinson Disease
Valerie C. Anderson, Kim J. Burchiel, Penelope Hogarth, Jacques Favre, and John P. Hammerstad
Arch Neurol. 2005;62(4):554-560.
ABSTRACT | FULL TEXT  

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Arch Neurol 2005;62:1644-1645.
FULL TEXT  

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Arch Neurol 2005;62:1642-1643.
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Multisite Randomized Trial of Deep Brain Stimulation
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Arch Neurol 2005;62:1643-1644.
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