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Are We Making Progress in Charting the Course?

Arch Neurol. 2005;62:351-352.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

While progressive motor and nonmotor decline is the expected natural course of Parkinson disease (PD), there is a remarkable paucity of data on what determines the rate of progression before and after the onset of symptoms. Using serial fluorodopa F 18 ([¹⁸F]fluorodopa) positron emission tomography (PET) in a prospective, longitudinal study of 31 patients with PD observed for more than 5 years, Hilker et al¹ found an annual decline in striatal [¹⁸F]fluorodopa ranging from 4.4% (caudate) to 6.3% (putamen). This is similar to other longitudinal studies of PD progression, using imaging ligands that either measure dopamine metabolism ([¹⁸F]fluorodopa PET) or target dopamine transporter (-carboxymethyoxy-3--[4-iodophenyl] tropane single-photon emission computed tomography), demonstrating an annualized rate of reduction in these striatal markers of about 4% to 13% in patients with PD compared with 0% to 2.5% change in healthy controls.^2-5 These imaging studies are consistent with pathological studies . . . [Full Text of this Article]

AUTHOR INFORMATION

Joseph Jankovic, MD

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