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Applications of Laser Capture Microdissection in the Study of Neurodegenerative Disease
David G. Standaert, MD, PhD
Arch Neurol. 2005;62:203-205.
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INTRODUCTION
Laser capture microdissection (LCM) is a new technology that is becoming increasingly important for studies of neurodegenerative disorders. A characteristic feature of all neurodegenerative diseases is "selective vulnerability." In each of the disorders, there is selective degeneration of particular types of neurons, with relative preservation of much of the rest of the brain. Familiar examples are the selective degeneration of dopaminergic neurons in Parkinson disease, the striking depletion of basal forebrain cholinergic neurons in Alzheimer disease, the selective atrophy of the caudate nucleus in Huntington disease, and the loss of spinal motor neurons in amyotrophic lateral sclerosis. Closer examination reveals an even more fine-grained pattern of neuronal injury. For example, in Parkinson disease there is striking depletion of dopaminergic neurons in the ventral tier of the substantia nigra pars compacta, with very little injury to dopaminergic neurons located only a few millimeters away in the . . . [Full Text of this Article]
METHODS
ANALYSIS OF LCM SPECIMENS
USE OF LCM IN THE STUDY OF NEUROLOGICAL DISORDERS
AUTHOR INFORMATION
Author Affiliations: Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston.
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