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Bread-and-Butter in Diagnosis of Myasthenia Gravis
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We read with interest the article by Dr Caress and associates about a patient presenting with ocular myasthenic features and positivity for antibodies to a muscle-specific kinase (MuSK).1 The diagnosis of myasthenia gravis in this case hinged on the demonstration of elevated serologic levels for anti-MuSK antibody, which, nevertheless, is not a technique readily available in every center.
Diagnosis of myasthenia gravis comprises clinical as well as investigatory evidences. Among the usual investigatory tools, the Tensilon (edrophonium chloride) test has been given the credit as a test of high sensitivity (80%-85%).2 Since the advent of the Tensilon test in 1950, it is still one of the most commonly employed diagnostic tests for myasthenia gravis.3-4
When we took a closer look at the diagnostic workup of this patient, we saw that the usual panel of tests such as the acetylcholine receptor antibody immunoassay and repetitive nerve stimulation had been performed, but . . . [Full Text of this Article] AUTHOR INFORMATION
Alice Y. K. Chan, MRCP;
David T. L. Liu, MRCS
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EXTRACT
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Anti-MuSK Myasthenia Gravis Presenting With Purely Ocular Findings
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ABSTRACT
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THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES
Ocular myasthenia: a rare presentation with MuSK antibody and bilateral extraocular muscle atrophy
Chan and Orrison
Br. J. Ophthalmol. 2007;91:842-843.
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