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edited by Stephen G. Waxman, MD, PhD, 496 pp, with illus, $170, ISBN 0-12-738761-7, Boston, Mass, Elsevier Academic Press, 2005.

Arch Neurol. 2005;62:1936-1937.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

Over the last 140 years, multiple sclerosis (MS) has come full circle. In the second half of the 19th century, Jean Martin Charcot and William Moxon were perhaps the first to recognize the presence of axonopathies in MS histopathologic examination findings. Max Bielschowsky, Otto Marburg, Russel Brain, and Charles Lumsden later confirmed their observations. Thus, it is surprising that until recently most medical textbooks referred to MS as a disorder of the central nervous system (CNS), characterized by destruction of the myelin with axonal sparing. In addition, much of the information about MS that is currently available on the Internet contains inaccuracies in this regard. For practicing neurologists, residents, and medical students, perhaps no scientific contribution has provided clarity on the histopathologic findings of MS lesions as dramatically as a relatively recent publication by Trapp et al¹ who showed that transected axons are a consistent feature of MS lesions. In . . . [Full Text of this Article]

AUTHOR INFORMATION

Olaf Stüve, MD, Reviewer; Wei Hu, MD, Reviewer

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