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I would like to address the article "Earlier Onset of Alzheimer Disease Symptoms in Latino Individuals Compared With Anglo Individuals," by Clark et al¹ recently published in the ARCHIVES. The design of the study is affected by problematic inclusion criteria and definition of the subjects; hence, the results and conclusions may be at risk.

The article uses the term Latino, but there is no information on this cohort’s composition: thus, the proportion of Caucasian, mestizo, and mulatto people, the typical genetic makeup of Latin American populations,² is not addressed. Latin American subjects in this study were not genetically uniform. Although Puerto Rican individuals on the East Coast of the continental United States have a greater prevalence of African genetics (from African American and mulatto people), most Mexican and Central American people on the West Coast are mestizo. Latin American Caucasian people are also substantially represented in both . . . [Full Text of this Article]

AUTHOR INFORMATION

Victor M. Rivera, MD

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