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Mild cognitive impairment (MCI) is a controversial entity. To date, enthusiasts of the MCI concept have supported their view with the finding of consistently higher incidence of Alzheimer disease in persons with MCI than in persons without MCI, while detractors have stressed that a large proportion of patients with MCI do not progress even after long follow-up periods. Maruyama et al¹ have recently reported in the ARCHIVES some findings that reconcile these opposing views by shedding light on the natural history of MCI subtypes. However, some inconsistencies with data from the literature deserve comment.

They studied 57 patients with amnestic MCI and found that 16 remained stable during an average follow-up of 2 years. Compared with those who progressed, patients with stable MCI showed lower levels of an Alzheimer disease marker (cerebrospinal fluid tau) and higher levels of white matter lesions (WMLs). Albeit cautiously, the authors suggest that stable . . . [Full Text of this Article]

AUTHOR INFORMATION

Giovanni B. Frisoni, MD; Cristina Geroldi, MD, PhD; Giuliano Binetti, MD; Orazio Zanetti, MD

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