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Magnetic Resonance Imaging Reveals Selective Vulnerability of the Cerebellum and Basal Ganglia in Malignant Hyperthermia
Arch Neurol. 2004;61:1462-1463.
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A 47-year-old man was admitted for facial bone surgery after a mandibular fracture. Anesthesia was induced with thiopental sodium following succinylcholine administration. Intubation was performed without difficulty and anesthesia was maintained with enflurane and nitrous oxide.
Near the end of the procedure, his heart rate increased gradually to 120/min and his rectal temperature rose rapidly to 42°C. There was no evidence of external bleeding and blood pressure was maintained between 120/80 and 100/70 mm Hg. Malignant hyperthermia was tentatively diagnosed and surgery was stopped. The patient was placed in an ice pack, treated with intravenous dantrolene, and hyperventilated with 100% oxygen.
Over the next several hours, the patient's temperature fell to 37.5°C. Cooling was successfully discontinued with no significant fluctuation in systemic blood pressure, or hypoxia. Serum creatine kinase values, measured at 69 U/L on admission, had increased to 16 043 U/L, and urine myoglobulin levels were elevated above 3000 . . . [Full Text of this Article]
AUTHOR INFORMATION
Jeong-Wook Park, MD;
Young-Bin Choi, MD;
Soung-Kyung Park, MD;
Yeong-In Kim, MD;
Kwang-Soo Lee, MD
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