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Progress, Challenges, and Limitations

Erik J. Kobylarz, MD, PhD; Nicholas D. Schiff, MD

Arch Neurol. 2004;61:1357-1360.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

INTRODUCTION

Despite the wide application of functional neuroimaging techniques to the study of neurological disorders, few reports have examined patterns of brain activity following severe injuries. In this review, we discuss recent functional brain imaging studies of patients in the vegetative state (VS) and pilot studies of patients meeting diagnostic criteria for the newly formulated minimally conscious state (MCS).¹ These neuroimaging studies support the clinical model of VS and provide neurophysiologic correlates of the condition. In addition, the studies suggest a foundation for the conceptual separation of VS and MCS on the basis of distinct physiological underpinnings. We consider the widely varying responses drawn by the definition of MCS^2-3 and argue for the relevance and importance of nosological distinctions, even within the lowest functional levels observed among patients who remain severely disabled. As further neuroimaging efforts are applied to study the outcomes . . . [Full Text of this Article]

NOSOLOGY

FUNCTIONAL BRAIN IMAGING TECHNIQUES AND STUDIES OF THE VEGETATIVE STATE

APPROACHING THE MINIMALLY CONSCIOUS STATE: INITIAL IMAGING STUDIES AND PATHOLOGICAL SUBSTRATES

OTHER DEFINITIONAL AND ETHICAL CONSIDERATIONS

AUTHOR INFORMATION

Author Affiliations: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, NY.

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