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Intersections Between Neurodegeneration and Cholesterol Metabolism

Arch Neurol. 2004;61:1178-1180.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

The brain contains more cholesterol than any other organ in the body, and cholesterol metabolism plays a large role in the health of our nerve cells. Abnormalities in cholesterol-related genes appear to increase the risk of Alzheimer disease (AD) possibly by increasing production of the neurotoxic peptide, amyloid-. The study in the ARCHIVES by Scherzer et al¹ identifies another important mechanism showing that cholesterol metabolism affects neurodegeneration. Scherzer et al show that brains from donors with AD exhibit greatly reduced levels of the apolipoprotein E (ApoE) receptor LR11, which is a lipoprotein receptor that is pres ent in the brain as well as the periphery. This observation provides important insights into how cholesterol metabolism changes in degenerating neurons.

The team began the study using gene arrays to screen RNA from AD and control lymphoblasts with the goal of identifying transcriptional changes associated with AD. Many transcripts were . . . [Full Text of this Article]

AUTHOR INFORMATION
Benjamin Wolozin, MD, PhD

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