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Arch Neurol. 2004;61:1007-1008.

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Determining the occurrence of disease(s) in families is a traditional strategy to begin the study of genetic causation. Typically, as diseases cluster in families, the likelihood of a genetic basis for the disease is thought to increase, assuming, of course, no known common, causative environmental exposure. Family studies have formed the basis for many analytic genetic methods, including association, segregation, and linkage analyses; such studies focus on description, characterization, and identification of potential disease-causing genes. In this issue of the ARCHIVES, Levy et al¹ use a basic family history design to describe the occurrence of Alzheimer disease (AD) among the relatives of persons with Parkinson disease (PD) as compared with AD occurrence in relatives of similar persons without PD. Because AD and PD are both neurodegenerative diseases, occurrence of one could possibly predispose family members to occurrence of the other, if similar etiologic disease genes were in play. Specifically, Levy . . . [Full Text of this Article]

Walter A. Kukull, PhD

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