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Arch Neurol. 2004;61:1006.

	Since this article does not have an abstract, we have provided the first 150 words of the full text and any section headings.

In 1940, Mount and Reback¹ described familial paroxysmal choreoathetosis in a report in the ARCHIVES, more than 60 years ago. Known also as paroxysmal dystonic choreoathetosis (PDC) (Mendelian Inheritance in Man No. 11880) and paroxysmal nonkinesigenic dyskinesia, it is a movement disorder in which episodes of dystonia, chorea, and athetosis begin in childhood through early adulthood; involve the extremities, trunk, and face; and may be associated with dysarthria and dysphagia. These episodes are of varying lengths—from minutes to an hour—and may recur several times a day. Paroxysmal movements may occur spontaneously while at rest or may be precipitated by alcohol or caffeine use, fatigue, hunger, or emotional stress.

Fink et al^2-3 mapped this disorder on chromosome 2q in 1996, and in 1997 they described the essential issues involved in its pathophysiologic features. Now in this issue of the ARCHIVES, Rainier et al⁴ report the identification of the PDC gene. . . . [Full Text of this Article]

Roger N. Rosenberg, MD, Editor

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Myofibrillogenesis Regulator 1 Gene Mutations Cause Paroxysmal Dystonic Choreoathetosis
Shirley Rainier, Donald Thomas, Debra Tokarz, Lei Ming, Melanie Bui, Erin Plein, Xinping Zhao, Rosemary Lemons, Roger Albin, Colin Delaney, David Alvarado, and John K. Fink
Arch Neurol. 2004;61(7):1025-1029.
ABSTRACT | FULL TEXT